Background
Ultimately, the goal of much biomedical and behavioral research is to yield new or improved diagnostics and therapeutics to prevent and treat conditions and to enhance quality-of-life. More powerful methods and tools are needed to enable translation of basic discoveries into new or improved interventions. Diagnostics and therapeutics must also be developed or adapted to meet the needs of specific populations, including infants, children, women, and persons with disabilities, while remaining sensitive to complex developing systems. In addition, the effects of current clinical practice on these populations must be better understood to ensure that all may benefit.
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